Abstract: In order to solve the problems of complex leakage and collapse, low rate of penetration, and high requirements for cementing integrity during drilling and completion in Dongsheng Gas Field of Dongsheng Gas Field, key drilling and completion technologies were studied based on the analysis of engineering geological characteristics. Efficient prevention and treatment technologies for leakage and collapse were formed by optimizing the casing program and developing KCl−polyamine strong plugging drilling fluid system and KPD plugging slurry. Drilling speed enhancement technology for heterogeneous formation was developed by designing personalized PDC bits and drilling parameters, optimizing bottom hole assembly, and supporting wellbore trajectory control. Horizontal well cementing technology for low pressure-bearing formation was formed by developing ultra-low density cement slurry, elastic and ductile anti-channeling cement slurry, supporting technology of fully sealed cementing, and achieving efficient displacement, tail pipe suspension, and reconnection process. The above key technologies for drilling and completion have been integrated and applied in 94 horizontal wells in Dongsheng Gas Field, reducing the average drilling cycle by 34.4% and the completion cycle by 32.1%, increasing the cementing quality rate from 26.7% to 84.3%. The research and application results indicate that the key technologies for drilling and completion in Dongsheng Gas Field have a significant effect on speed improvement and cost reduction, providing engineering and technical support for the economic development of tight gas reservoirs in the northern edge of Ordos Basin.