Abstract: In the second spud of Well SBY-1, the ϕ444.5 mm drill bit is used to drill to the depth of 5 395.00 m, and put in the ϕ339.7 mm technical casing. There are a series of technical problems in casing running and cementing operation, such as heavy casing suspension, long open hole section, development of leaky layer of Permian igneous rock, lack of experience in running super deep and large-scale graded cement injector, etc., which are very easy to cause complex working conditions such as sticking in casing running and loss of return in cementing. Therefore, it is urgent to optimize the matching technology to ensure the cementing quality. According to the special working conditions of Well SBY-1, through load checking calculation, well passing measures strengthening, casing running speed and drilling fluid performance optimization, a large-scale casing running technology of ultra deep well is formed; through discontinuous staged cement injection technology and low-density leak proof cement slurry system optimization, the cementing technology of ultra deep and large-scale casing is improved. Based on the above measures, the second spud in casing of Well SBY-1 is running smoothly, and the cementing quality of the leaky zone is medium, which realizes effective sealing. The research results could be used for reference for large-scale casing running and cementing construction in ultra deep wells, and effectively ensure the safe and efficient development of Shunbei Oil and Gas Field.