Abstract: Aiming at the industrial problems of low separation efficiency of traditional solid-phase control equipment, high liquid content of oil-based cuttings, poor environmental protection performance under high-density drilling fluid working conditions in deep and complex formation drilling operations, as well as high energy consumption, low cost performance and difficulty in large-scale application of imported negative pressure screening equipment, an electric micro-vibration negative pressure shale shaker is developed in this paper. Replacing the traditional pneumatic vibrator with a vibration motor, the equipment constructs an electric micro-vibration system, combined with negative pressure suction, rotating screen and integrated cleaning and chip removal mechanism, to strengthen the solid-liquid separation effect through the synergistic effect of micro-vibration and negative pressure, and effectively reduce equipment energy consumption and operating cost. In this study, the dynamic equation of the vibrating screen frame is established to clarify the micro-vibration working mechanism of the equipment. Three-dimensional modeling and finite element simulation are adopted to carry out fatigue characteristic and modal analysis of the screen frame, which verifies that the equipment structure has no resonance risk and the fatigue strength meets the requirements of long-term continuous operation. Field applications in two oil-based drilling fluid wells in the Southwest Work Area of Sinopec show that the equipment is adaptable to screens with apertures below 50 μm. Under high-density drilling fluid working conditions, the single-screen processing capacity exceeds 10.6 L/s, and the volumetric liquid content of cuttings is stably controlled within 30%. Compared with traditional equipment, it can effectively reduce drilling fluid loss and solid waste discharge, cut down drilling operation costs, and has the advantages of energy saving, environmental protection and strong adaptability. Capable of replacing imported equipment, it provides efficient and reliable new equipment support for fine solid-phase control of high-density drilling fluid, with great engineering promotion value.