Abstract: Lost circulation occurs frequently during long open-hole cementing in ultra-deep wells, and the lost circulation problem is particularly prominent in the Permian formations of the Tarim Basin, which easily leads to the sealing failure of long-section casing, urgently requiring the optimization of construction processes to ensure wellbore integrity. Based on the formation characteristics of ultra-deep fractured reservoirs in the Tarim Basin and combined with the formation pressure-bearing capacity of target wells, systematic research was conducted from three aspects: sealing and staged cementing technology, cement slurry system, and supporting key cementing tools. By increasing the return height of cement slurry in primary cementing and sealing lost circulation zones with packers, the cement slurry in secondary cementing was ensured to return to the surface, which effectively shortened the uncemented casing section, achieved the goals of reduced lost circulation in primary cementing and zero lost circulation in secondary cementing, and comprehensively guaranteed wellbore integrity. This technology was applied on-site in more than 300 wells, improving the cementing quality pass rate by 30%–40%. It supports the implementation of optimized and efficient completion technologies for ultra-deep wells, enhances wellbore integrity, prolongs the service life of wellbores, and accelerates the exploration and development process in the Tarim Basin.