Abstract: Leakage occurs frequently during long open-hole cementing in ultra-deep wells, especially in the Permian formation of the Tarim Basin, which tends to result in the failure of long-section casing cementing. Therefore, it is urgent to optimize technical solutions to ensure wellbore integrity. Based on the geological characteristics of ultra-deep fractured reservoirs in the Tarim Basin and the formation pressure-bearing capacity of target wells, this paper systematically conducts research from three aspects: sealing and staged cementing technology, cement slurry system, and supporting key cementing tools. By increasing the cement slurry return height in primary cementing and sealing leakage zones with packers, the cement slurry in secondary cementing is ensured to return to the surface, which effectively shortens the length of empty casing and achieves the goal of low leakage in primary cementing and zero leakage in secondary cementing, thus comprehensively guaranteeing wellbore integrity. This technology has been applied in more than 300 well sites, improving the qualified rate of cementing quality by 30%～40%. It supports the high-efficiency and rapid completion of ultra-deep wells, enhances wellbore integrity, prolongs wellbore service life, accelerates the exploration and development of the Tarim Basin, and provides core technical support for safeguarding national energy security.