Abstract: To address the technical challenges in shale oil in the Shulu Sag in the Central Hebei Region, including coexistence kick and loss in the same layer of the third member of Shahejie Formation, severe wellbore instability, poor drillability of conglomerate formations, high friction and torque in horizontal sections, and difficult running of unlimited-stage fracturing sliding sleeves, systematic studies were carried out based on regional geological and engineering characteristics. The research involved casing program optimization, drilling speed improvement and friction reduction, amphiphobic drilling fluid system, graded lost circulation prevention and control, and casing string running and cementing technologies with unlimited-stage sleeves. A set of key drilling and completion technologies suitable for horizontal wells of shale oil in this block was formed. Field test results indicate that the proposed technologies can effectively solve the problems of coexistence of kick and loss, wellbore collapse, low rate of penetration, and difficult casing running. Compared with those of adjacent wells, the average drilling cycle of test wells was shortened by 23.02%, and the average rate of penetration was increased by 31.20% with excellent cementing quality. The technologies can provide technical support for the efficient exploration and development of Shulu and similar deep shale oil reservoirs.