Abstract: The Kuqa piedmont area has the characteristics of ultra-deep, ultra-high pressure, ultra-high temperature, high production, high-steep structure, and high risk. The formation pressure reaches up to 136 MPa; the safe drilling mud weight window is narrower than 0.02 kg/L; kick-loss conversion and simultaneous kick and loss occur frequently; the ultra-high temperature and ultra-high pressure overflow is highly concealed and difficult to handle, and well control safety issues are prominent. In view of technical shortcomings such as insufficient pre-drilling formation pressure prediction accuracy, poor adaptability of conventional casing programs, handling difficulties of simultaneous kick and loss, and insufficient pressure-bearing capacity of well control equipment, well control technologies suitable for the Kuqa piedmont area of Tarim Oilfield were developed. These technologies were achieved by establishing a three-dimensional pressure field prediction technology with multi-source fusion of geology, geophysics, and mechanics; optimizing and forming the Tabiao II-B casing program for specific isolation of salt layers and specific drilling of reservoirs; innovating complete well control techniques such as fine managed pressure control for ultra-high pressure brine, water discharge and pressure reduction, and overflow well killing by “bullheading + choke circulation”; developing supporting high-end equipments such as 140 MPa-grade casing heads, gas production trees, and choke manifolds. Field applications indicate that these technologies effectively solve the handling difficulties of narrow mud weight windows, simultaneous kick and loss, and ultra-high pressure overflow. The drilling cycle is significantly shortened, and the cost is greatly reduced, which provides strong technical support for the safe and efficient drilling of ultra-deep complex oil and gas wells in the Kuqa piedmont area.