Abstract: To address issues including excessive acid erosion causing sand production during acidification operations in loose sandstone reservoirs, as well as the complexity and high operational costs associated with combined acidification and sand consolidation processes, a novel acidification and sand consolidation integration system was developed. This system employed polysiloxane as the consolidation agent and utilized cocoamidopropyl betaine with 2-butoxyethanol ether as hydrolysis regulators. When the mass fraction of 2-butoxyethanol ether is 1.0%, the hydrolysis behavior of polysiloxane could be controlled by varying the mass fraction of cocoamidopropyl betaine. When the temperature was below 70 °C, and the hydrochloric acid mass fraction was less than 10.0%, a polysiloxane mass fraction ranging from 1.0% to 3.0% could achieve satisfactory sand column consolidation effects, while also providing sufficient pumpability time and good formation permeability. Microscopic experiments show that polysiloxane molecules form a hydrophobic siloxane film in situ on sand grain surfaces. These silicone films exhibit excellent uniformity and continuity, effectively blocking the direct transmission of fluid scouring forces to the sand grains. This synergizes with the Si−O−Si bond forces formed through polycondensation, collectively inhibiting sand grain detachment and migration to achieve sand consolidation. Therefore, the polysiloxane acidification and sand consolidation integration system achieves synergistic enhancement between acidification and sand consolidation. While ensuring effective sand control, it significantly reduces operational complexity and reservoir damage, providing new technological support for the efficient development of similar reservoirs.