Abstract: High-permeability zones and fractures are widely developed in vuggy-fractured carbonate reservoirs, and injected water can easily break through along the predominant pathway and enter the wellbore, resulting in a high failure rate of water shut-off operations. To address this issue, a wellbore water shut-off design concept based on loss control was proposed. The method used calcium carbonate as the primary loss control material, forming a comprehensive water shut-off technology involving downhole loss control, cement squeeze, and pressure-controlled flowback. Firstly, calcium carbonate suspension was injected in batches to seal the high-permeability channels, thereby enhancing the pressure-bearing capacity of the reservoir. Subsequently, the cement was squeezed, and the excess cement slurry was controlled to be returned to the wellbore to prevent the wellhead from being clogged. Finally, cable perforation and acidizing were performed to reconstruct the production capacity channel. The experimental results show that xanthan gum can effectively carry calcium carbonate particles and control lost circulation. The designed cement slurry system possesses excellent rheological properties and sealing performance. Field test results show that in Well A, the injectivity index decreases by 80% after water shut-off, and the water cut drops from 53% to 10%, achieving great effects. Studies have shown that the water shut-off technology based on loss control can solve the problem of cement slurry leakage during water plugging in vuggy-fractured reservoirs. It has the advantages of cost-efficiency, high efficiency, and environmental friendliness and provides a new technical approach for water shut-off operations in similar reservoirs.