Abstract: Aggregation between hydrate particles and adhesion to the borehole wall are important causes of wellbore plugging during deepwater operations. In order to investigate the effects of different factors on the aggregation of hydrate particles and adhesion to the borehole wall, the effects of temperature, contact time, and environmental medium on the cohesive force between cyclopentane hydrate particles and their adhesive force to the borehole wall were analyzed with the help of a hydrate particle interaction force test device, and the effects of the cocamide surfactant DEA on the inhibition of hydrate aggregation and adhesion were investigated with combination of hydrate clogging evaluation experiments. The results show that the cohesive force between hydrate particles and the adhesive force between particles and walls increase as temperature and contact time increase; the interaction forces in air are higher than those in liquid-phase cyclopentane; the hydrate particles show the smallest adhesive force to hydrophobic surfaces. DEA can effectively reduce the cohesive force between hydrate particles and the adhesive force between particles and the wall in both liquid-phase cyclopentane and air. At a concentration of 0.5%, it reduces the cohesive force by 51% and 53% and the adhesive force by 82% and 60%, respectively. In the high-pressure and low-temperature conditions, it can inhibit the aggregation and adhesion of hydrates. The results show that DEA has good compatibility with deepwater water-based drilling fluid and it can be used as a dual-action hydrate inhibitor for deepwater drilling fluids.