Abstract: Chemical sand control technology aims to prevent sand production from the source; however, its application remains limited due to challenges such as high permeability damage, low consolidation strength, and short validity period. To address these issues, this study developed a water-based nano-solution sand consolidation system by grafting cross-linking reactive groups and hydrophilic groups onto the surface of inorganic nanoparticles. A comprehensive experimental evaluation was conducted, including particle size analysis, sand consolidation performance, permeability retention, and temperature adaptability. The results demonstrate that the median particle size of the system is 58 nm, exhibiting excellent consolidation effects for formation sands ranging from 0.05 to 0.85 mm, particularly for fine silty sands. The consolidated sand achieved a strength of 6–12 MPa and a permeability retention value of 86.19%, meeting the requirements for reservoirs at 40–120 ℃. Field applications in the Liaohe Oilfield confirmed a 100% success rate in sand control, with post-treatment fluid and oil production fully restored to pre-sand-control levels. This technology integrates high strength, low damage, and environmental adaptability, offering significant practical value for addressing sand issues in unconsolidated sandstone reservoirs.