Abstract: In order to provide a theoretical basis for optimizing horizontal well volume fracturing design and reducing the blockage and sticking risks during running fracturing tools, a self-developed large-scale field experiment simulation system for perforation erosion was utilized to conduct experiments on the casing and fracturing materials under the erosion of high-speed sand-carrying fluid. Based on the experimental data, a dynamic model was established to describe the erosion morphology of the perforation inner wall. The experimental results show that as the sand concentration in the sand-carrying fluid increases, the maximum diameter of the inner wall of the perforation and the pumping pressure drop gradually increase after erosion. The thickness of the proppant attached on the inner wall of the casing gradually increases from the heel to the toe of the wellbore, which can reduce the inner diameter of the lower string by 35 mm. As the sand concentration gradually increases, the adhesion amount gradually increases at the heel but gradually decreases at the toe of the casing. Moreover, as the sand concentration in the sand-carrying fluid increases, the degree of proppant fragmentation after erosion gradually becomes stronger, with the debris ratio going up. The reduction amplitude of fracturing fluid viscosity after erosion goes up first and then goes down, and the maximum reduction of fracturing fluid viscosity can reach 52%. A numerical model of proppant migration in the casing under high-speed erosion condition was established, and the law of proppant particle migration in the casing was analyzed. In addition, the dynamic model derived from the experiment was verified, which describes the erosion morphology of the inner wall of the perforation. The research results provide a basis for optimizing construction parameters of horizontal well fracturing and reducing the blockage and sticking risks during running fracturing tools.