Abstract: When drilling sulfur-containing oil and gas wells, safe drilling requires effective detecting the change of sulfide scavenger content and maintaining the effective concentration of it in drilling fluids. Given this, according to the linear relationship between sulfide reaction reagent and zinc-based sulfide scavenger, a relational expression utilized the indirect method was established for the content of sulfide scavenger and the consumption rate of sulfide reaction reagent. In addition, the consumption rate of sulfide reaction reagent in drilling fluids was analyzed by titration. Based on the above works, the detection method for effective content of sulfide scavenger was proposed and its accuracy was verified. The results showed that the detection method could effectively detect the content of sulfide scavenger in drilling fluids, with an absolute value of relative measurement error less than 5%. The result of the field test of the method showed that it could effectively detect the content change of sulfide scavenger in drilling fluids, thereby effectively maintaining the effective content of sulfide scavenger in drilling fluids in time. The research results demonstrate that the detection method can meet the requirements of field engineering application, effectively guarantee the safe drilling of sulfur-containing well sections, and avoid the waste of excessive use of the sulfide scavenger.