Abstract: Reservoirs in the Lucaogou Formation of the Jimsar Sag have poor physical properties, strong heterogeneity, and poor crude oil fluidity. Accordingly, it is difficult to accurately stimulate favorable reservoirs with horizontal wells, and staged fracturing has only a limited positive effect on production. Contradiction is highlighted by the fact that a high investment yields only a low level of output. In order to solve these problems, non-uniform limited-entry perforation was conducted to improve the distribution of fracturing fluid in the fracture clusters in the sections. Temporary plugging at the fracture entrance and in the fracture were adopted to increase the net pressure, so as to generate complex fracture networks. In addition, fracturing parameters were optimized to facilitate the balanced initiation of multiple clusters of fractures in the sections. Finally, the large-section and multi-cluster fracturing technology suitable for the horizontal wells in the Jimsar shale oil reservoir was developed. Field applications showed that the technology can enhance the stimulation and production of shale oil reservoirs, and provide strong support for the economic and effective development of the shale oil reservoir in the Jimsar Sag.