Abstract: To solve the problem of low primary production and quick decline of horizontal wells after hydraulic fracturing in Chang 8 Formation of Jinghe Reservoir, coiled tubing hydraulic sand blasting perforation and multiple clusters fracturing technique was proposed. Through the analysis of this techniques characteristics, the optimization of cluster spacing, perforation and treatment parameters were optimized. Based on the optimum treatment design, we set cluster spacing to 15-38 m, pad ratio 28%-32%, sand plug 25-45 m3, average sand ratio 25.5%-27%. This technique has been put in 9 wells design and it showed that treatment success rate had increase 39.3% and single well production increased 3.5 tons per day. Through the application, it demonstrated that coiled tubing hydraulic sand blasting perforation, and multiple clusters fracturing technique is effective in the development of sandstone reservoirs with low porosity, low permeability.